Which setup.py to use?

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I want to embed the plotter Veusz in a Python script. According to the Veusz instructions, the path to Veusz should be on the Python path and one is advised to do this in setup.py. (Python 3.8 here). There are 123 files on my computer called setup.py and 29 of them are in /opt/local. Which one should I use? Is there one that sits “higher” so that non-Macports Pythons can also see it?

Jerry